研讨部队名字:　杨春皓性别:　男职称:　研讨员学历:　博士电话:　021-50806600-3512传真:　021-50806770电子邮件:　chyang@mail.shcnc.ac.cn自个主页:　通讯地址:　上海市浦东新区祖冲之路555号　201203简历:1992年结业于姑苏大学化学系。1995年于华东师范大学化学系硕士结业。其下一任职于南通医学院，从事有机化学的教育作业。2003年获我国科学院上海药物研讨所理学博士学位。2008年在georgiastateuniversity化学系做造访专家。研讨方向:

新式抗肿瘤药物研发生物活性为导向的杂环办法学研讨

专家品种:研讨员职务:中科院上海药物所研讨

员科研作用:承担科研项目情况:

新式parp1抑制剂的方案优化和成药性研讨(2012zx09103-101-071），“十二五”国家严从头药创制严峻专项，2012.1－2015.12高选择性parp-1抑制剂的方案、组成及抗肿瘤活性研讨（21072205），国家天然基金面上项目，2011.1－2013.12以pi3k－akt－mtor为通路的特异性抑制剂方案、优化及信号转导研讨（90713034），国家天然基金严峻研讨方案“化学小分子探针”项目，2008.1—2010.12pi3k-mtor两层/多重抑制剂的方案、组成及信号机制研讨（09jc1416600），上海市科委基础研讨严峻项目，2009.9－2011.8雌激素受体β亚型选择性配体的方案、组成与生物活性研讨（20502028），国家天然基金面上项目，2006.1—2008.12

社会任职:获奖及荣誉:代表论著:

yu-qinwang,xiao-huali,qianhe,yichen,yu-yuanxie,jianding,ze-hongmiao,*andchun-haoyang*design,synthesisandbiologicalevaluationofsubstituted11h-benzo[a]carbazole-5-carboxamidesasnovelantitumoragents.eur.j.med.chem.2011,inpress.xiaochuanyang,guojingsun,chunhaoyang,*binghewang.*novelrheinanaloguesaspotentialanticanceragents.chemmedchem2011,doi:10.1002/cmdc.201100384.haixiapeng,xuxingchen,yanhongchen,qianhe,yuyuanxie,chunhaoyang*solvent-freesynthesisofδ-carbolines/carbazolesfrom3-nitro-2-phenylpyridines/2-nitrobiphenylderivativesusingdppeasareducingagent.tetrahedron2011,67，5725-5731.yanhongchen,haoyuexiang,yuyuanxie,andchunhaoyang﹡convenientone-potsynthesisof3-aryl-2h-chromene-4-carbonitrilesviaatandemo-alkylation-knoevenagelcondensation.heterocycles2011,83(6),1355-1361.tingli,jiawang,xiangwang,nayang,si-mengchen,lin-jiangtong,chun-haoyang,ling-huameng,andjianding.wjd008,adualphosphatidylinositol3-kinase(pi3k)/mammaliantargetofrapamycininhibitor,preventspi3ksignalingandinhibitstheproliferationoftransformedcellswithoncogenicpi3kmutant.j.pharmacol.exp.ther.2010,334,830-838.yanhongchen，chunhaoyang,*yuyuanxie.synthesisof4-azachromeno[2,3-b]indol-11(6h)-oneanditsderivativesasanaloguesofellipticine.heterocycles2010，80（1），251－258.minjiang,tingli,linghuameng,chunhaoyang,*yuyuanxie,andjianding.directpalladium-catalyzedarylationsofarylbromideswith2/9-substitutedpyrimido[5,4-b]indolizines.journalofcombinatorialchemistry2009,11,806-808.zhangc,yangn,yangc-h,dingh-s,luoc,etal.s9,anovelanticanceragent,exertsitsanti-proliferativeactivitybyinterferingwithbothpi3kakt-mtorsignalingandmicrotubulecytoskeleton.plosone2009,4(3):e4881.chendd,xuj,yangch,*xieyy.*facilesynthesisof1,2,3,4-tetrahydrobenzo[b][1,8]-naphthyridin-2-oneviabaylis-hillmanadducts.chinesejournalofchemistry,2009,27,787—790.chunhaoyang,*haofeiyu,nayang,linghuameng,jingxu,rongpingzhang,yuyuanxieandjiandingsynthesisof4-(5-benzyl-2-phenylpyrimidin-4-yl)morpholinesasnovelpi3kinhibitorsviaacetatesofbaylis-hillmanadductsandbenzamidines.lettersinorganicchemistry2009,6(2),134-140.minjiang,qianhe,chunhaoyang,*yuyuanxie.synthesisof2-substitutedpyrimido[5,4-b]indolizinederivativesfromacetatesofbaylis-hillmanadducts.heterocycles2008,75(11),2659-2666.wuhongchen,zhaohulin,mengmengning,,chunhaoyang,*xuemingyan,yuyuanxie,xushen,andming-weiwang*azaanaloguesofequol:novelligandsforestrogenreceptorβbioorganic&medicinalchemistry15,2007,5828-5636.maojiangwu,qimingsun,chunhaoyang,*dongdongchen,jianding,*yichen,lipinglinandyuyuanxiesynthesisandactivityofcombretastatina-4analogues:1,2,3-thiadiazolesaspotentantitumoragents.bioorganic&medicinalchemistryletters17(4),2007,869–873.mning,czhou,jweng,szhang,dchen,cyang,*hwang,jren,lzhou,cjinandm-wwang.*biologicalactivitiesofanovelselectiveoestrogenreceptormodulatorderivedfromraloxifene(y134)britishjournalofpharmacology2007,150(1),19-28.wuhongchen,boliu,chunhaoyang,*yuyuanxie.convenientsynthesisof1,2,3,4-tetrahydroquinolinesviadirectintramolecularreductiveringclosuretetrahedronlett.2006,47(40),7191-7193.chunhaoyang,*guangyuxu,jiali,xihanwu,boliu,xuemingyan,mingweiwang,yuyuanxie.benzothiophenescontainingapiperazinesidechainasselectiveligandsfortheestrogenreceptorαandtheirbioactivitiesinvivobioorg.med.chem.lett.2005,15(5),1505-1507.qinggangji,jiegao,junbowang,chunhaoyang*,xinhui,xuemingyan,xihanwu,yuyuanxie,ming-weiwangbenzothieno[3,2-b]indolederivativesaspotentselectiveestrogenreceptormodulatorsbioorg.med.chem.lett.2005,15(11),2891-2893.huashengding,chaozhang,xihanwu,chunhaoyang,*xiongwenzhang,jianding,yuyuanxienovelindoleα-methylene-γ-lactonesaspotentinhibitorsforakt-mtorsignalingpathwaykinasesbioorg.med.chem.lett.2005,15,4799-4802.boliu,chunhaoyang,guangyuxu,yonghongzhu,jingrongcui,xihanwuandyuyuanxiesynthesesofquinolonehydrochlorideenantiomersfromsynthons(r)-and(s)-2-methylpiperazinebioorg.med.chem.2005,13(7),2451-2458.yulixie,huashengding,lihuiqian,xuemingyan,chunhaoyang,andyuyuanxiesynthesisandbiologicalevaluationofnovelbisphosphonateswithdualactivitiesonboneinvitrobioorg.med.chem.lett.2005,15(13),3267-3270.